RNA Repair: An Antidote to Cytotoxic Eukaryal RNA Damage
Copyright policy )RNA Repair: An Antidote to Cytotoxic Eukaryal RNA Damage
RNA healing and sealing enzymes drive informational and stress response pathways entailing repair of programmed 2',3' cyclic PO(4)/5'-OH breaks. Fungal, plant, and phage tRNA ligases use different strategies to discriminate the purposefully broken ends of the anticodon loop. Whereas phage ligase recognizes the tRNA fold, yeast and plant ligases do not and are instead hardwired to seal only the tRNA 3'-OH, 2'-PO(4) ends formed by healing of a cyclic phosphate. tRNA anticodon damage inflicted by secreted ribotoxins such as fungal gamma-toxin underlies a rudimentary innate immune system. Yeast cells are susceptible to gamma-toxin because the sealing domain of yeast tRNA ligase is unable to rectify a break at the modified wobble base of tRNA(Glu(UUC)). Plant andphage tRNA repair enzymes protect yeast from gamma-toxin because they are able to reverse the damage. Our studies underscore how a ribotoxin exploits an Achilles' heel in the target cell's tRNA repair system.
- Cornell University United States
- Kettering University United States
- University of Leicester United Kingdom
Saccharomyces cerevisiae Proteins, Glu, Antidotes, Molecular Sequence Data, Arabidopsis, Saccharomyces cerevisiae, Killer Factors, Substrate Specificity, RNA, Transfer, Toxins, Bacteriophages, Molecular Biology, Toxins, Biological, Base Sequence, Cell Death, Arabidopsis Proteins, RNA Ligase (ATP), RNA, Fungal, Cell Biology, Mycotoxins, Biological, Yeast, Killer Factors, Yeast, RNA, Transfer, Glu, Transfer, Fungal, Eukaryotic Cells, RNA, Nucleic Acid Conformation
Saccharomyces cerevisiae Proteins, Glu, Antidotes, Molecular Sequence Data, Arabidopsis, Saccharomyces cerevisiae, Killer Factors, Substrate Specificity, RNA, Transfer, Toxins, Bacteriophages, Molecular Biology, Toxins, Biological, Base Sequence, Cell Death, Arabidopsis Proteins, RNA Ligase (ATP), RNA, Fungal, Cell Biology, Mycotoxins, Biological, Yeast, Killer Factors, Yeast, RNA, Transfer, Glu, Transfer, Fungal, Eukaryotic Cells, RNA, Nucleic Acid Conformation
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