Discovery of Fluoromethylketone-Based Peptidomimetics as Covalent ATG4B (Autophagin-1) Inhibitors
Copyright policy ) Zongxing, Qiu; Bernd, Kuhn; Johannes, Aebi; Xianfeng, Lin; Haiyuan, Ding; Zheng, Zhou; Zhiheng, Xu; +11 Authors
Zongxing, Qiu; Bernd, Kuhn; Johannes, Aebi; Xianfeng, Lin; Haiyuan, Ding; Zheng, Zhou; Zhiheng, Xu; Danqing, Xu; Li, Han; Cheng, Liu; Hongxia, Qiu; Yuxia, Zhang; Wolfgang, Haap; Claus, Riemer; Martin, Stahl; Ning, Qin; Hong C, Shen; Guozhi, Tang;
Discovery of Fluoromethylketone-Based Peptidomimetics as Covalent ATG4B (Autophagin-1) Inhibitors
ATG4B or autophagin-1 is a cysteine protease that cleaves ATG8 family proteins. ATG4B plays essential roles in the autophagosome formation and the autophagy pathway. Herein we disclose the design and structural modifications of a series of fluoromethylketone (FMK)-based peptidomimetics as highly potent ATG4B inhibitors. Their structure-activity relationship (SAR) and protease selectivity are also discussed.
- University of California, San Diego United States
- Roche (Switzerland) Switzerland
- Roche (China) China (People's Republic of)
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selected citations
Citations provided by BIP!
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Citations provided by BIP!popularityPopularity provided by BIP!
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
Popularity provided by BIP! 56
Top 10%
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