The algorithm for dia-gnosing and treating HCC has been relatively stable for many years. In the last few years, there has been clear progress, which is reflected in the international recommendations and in our recommendations, which are set out in the Blue Book of the Czech Oncological Society.Current developments in the dia-gnosis and treatment of hepatocellular carcinoma (HCC) are well illustrated by selected presentations from this years Gastrointestinal Cancers Symposium in San Francisco and the American Society for Clinical Oncology Annual Meeting 2020. The review will focus on selected news from the dia-gnostics as well as surgical and interventional treatment of HCC, systemic treatment and a combination of these modalities.