The kinin-kallikrein system and endogenous intoxication play an important role in the course of chronic pancreatitis (CP) with concomitant diabetes mellitus.The objective: of our work was to investigate the effect of diabetes mellitus on the parameters of the kinin-kallikrein system and endotoxicosis in patients with CP.Materials and methods. The study involved 112 patients with CP that were divided into 2 groups: I group – 35 patients with CP without diabetes; II group – 77 patients with CP with concomitant diabetes. The comparison group included 20 healthy individuals who did not have any complaints from the digestive tract.Results. A statistically significant increase in the factor of immune genesis in patients with CP with diabetes was found, in comparison with patients with CP and control group (p<0.05).Conclusions. A statistically significant activation of proteolytic activity, increase of the proteolytic enzyme of the kallikrein, decrease of the prekallikrein level, increase of the α1-proteinase inhibitor and α2-macroglobulin levels and decrease of the kininase-II activity, an increase in endotoxicosis in patients with CP with concomitant diabetes (p<0,05) compared to patients with only CP have been proved. It revealed the complicating role of diabetes mellitus in the disorder of the calicreatin-kinin system and endogenous intoxication in the presence of a comorbid course of it with chronic pancreatitis, which must be taken into account in the formation of therapeutic tactics.