Disturbance of cerebellar synaptic maturation in mutant mice lacking BSRPs, a novel brain‐specific receptor‐like protein family
Copyright policy )Disturbance of cerebellar synaptic maturation in mutant mice lacking BSRPs, a novel brain‐specific receptor‐like protein family
By DNA cloning, we have identified the BSRP (brain‐specific receptor‐like proteins) family of three members in mammalian genomes. BSRPs were predominantly expressed in the soma and dendrites of neurons and localized in the endoplasmic reticulum (ER). Expression levels of BSRPs seemed to fluctuate greatly during postnatal cerebellar maturation. Triple‐knockout mice lacking BSRP members exhibited motor discoordination, and Purkinje cells (PCs) were often innervated by multiple climbing fibers with different neuronal origins in the mutant cerebellum. Moreover, the phosphorylation levels of protein kinase Cα (PKCα) were significantly downregulated in the mutant cerebellum. Because cerebellar maturation and plasticity require metabotropic glutamate receptor signaling and resulting PKC activation, BSRPs are likely involved in ER functions supporting PKCα activation in PCs.
- Kyoto University Japan
- Osaka University Japan
- Hokkaido University Japan
- Tohoku University Japan
- Hokkeido University Japan
Mice, Knockout, Genome, Protein Kinase C-alpha, Down-Regulation, Nerve Tissue Proteins, Dendrites, Enzyme Activation, Mice, Mice, Neurologic Mutants, Purkinje Cells, Knockout mouse, Receptors, Glutamate, Protein kinase C, Cerebellum, Multigene Family, Synapses, Animals, Phosphorylation, Protein Processing, Post-Translational, Endoplasmic reticulum, Psychomotor Performance, Signal Transduction
Mice, Knockout, Genome, Protein Kinase C-alpha, Down-Regulation, Nerve Tissue Proteins, Dendrites, Enzyme Activation, Mice, Mice, Neurologic Mutants, Purkinje Cells, Knockout mouse, Receptors, Glutamate, Protein kinase C, Cerebellum, Multigene Family, Synapses, Animals, Phosphorylation, Protein Processing, Post-Translational, Endoplasmic reticulum, Psychomotor Performance, Signal Transduction
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