Lack of association between adolescent idiopathic scoliosis and previously reported single nucleotide polymorphisms in MATN1, MTNR1B, TPH1, and IGF1 in a Japanese population
Copyright policy )Lack of association between adolescent idiopathic scoliosis and previously reported single nucleotide polymorphisms in MATN1, MTNR1B, TPH1, and IGF1 in a Japanese population
AbstractAdolescent idiopathic scoliosis (AIS) is a spinal deformity most commonly arising in apparently healthy girls around puberty. AIS has a strong genetic predisposition. Several genetic associations between AIS and single nucleotide polymorphisms (SNPs) have been reported; common SNPs in the genes for matrilin 1 (MATN1), melatonin receptor 1B (MTNR1B), tryptophan hydroxylase 1 (TPH1), and insulin‐like growth factor 1 (IGF1) are reported to be associated with AIS in Chinese. However, these associations have not been replicated so far. To confirm the associations, we compared these SNPs with AIS predisposition and curve severity in a population of Japanese females consisting of 798 AIS patients and 1,239 controls. All the subjects were genotyped using the PCR‐based Invader assay. We found no association of any of the SNPs with AIS predisposition or curve severity. Considering the statistical power and sample size of the present study, we concluded that these SNPs are not associated with either AIS predisposition or curve severity in Japanese. © 2011 Orthopaedic Research Society Published by Wiley Periodicals, Inc. J Orthop Res 29: 1055–1058, 2011
- Boston Children's Hospital United States
- National Hospital Organization Japan
- RIKEN Japan
- Meijo Hospital Japan
- Hokkaido University Japan
Extracellular Matrix Proteins, Adolescent, Genotype, Receptor, Melatonin, MT2, Cartilage Oligomeric Matrix Protein, Middle Aged, Tryptophan Hydroxylase, Polymorphism, Single Nucleotide, Asian People, Japan, Scoliosis, Animals, Humans, Matrilin Proteins, Female, Genetic Predisposition to Disease, Insulin-Like Growth Factor I, Child, Aged, Glycoproteins
Extracellular Matrix Proteins, Adolescent, Genotype, Receptor, Melatonin, MT2, Cartilage Oligomeric Matrix Protein, Middle Aged, Tryptophan Hydroxylase, Polymorphism, Single Nucleotide, Asian People, Japan, Scoliosis, Animals, Humans, Matrilin Proteins, Female, Genetic Predisposition to Disease, Insulin-Like Growth Factor I, Child, Aged, Glycoproteins
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