The AP-2 transcription factor is required for joint formation and cell survival in Drosophila leg development
Copyright policy )The AP-2 transcription factor is required for joint formation and cell survival in Drosophila leg development
ABSTRACT Flies mutant for the Drosophila homologue of the mammalian transcription factor AP-2 show a severe reduction in leg length and fail to develop joint structures. Presumptive joint cells express dAP-2 in response to Notch signaling. dAP-2 is required for joint cell differentiation and can induce formation of supernumerary joints when misexpressed. Although dAP-2 is expressed only in presumptive joint cells, its activity is required to support cell survival in the entire leg segment. Taken together, our data indicate that dAP-2 is an important mediator of Notch activity in leg development.
- European Molecular Biology Laboratory Germany
- University of Zurich Switzerland
- European Bioinformatics Institute United Kingdom
Receptors, Notch, Cell Survival, Gene Expression, Membrane Proteins, Extremities, DNA-Binding Proteins, Transcription Factor AP-2, Animals, Drosophila Proteins, Drosophila, Joints, Transcription Factors
Receptors, Notch, Cell Survival, Gene Expression, Membrane Proteins, Extremities, DNA-Binding Proteins, Transcription Factor AP-2, Animals, Drosophila Proteins, Drosophila, Joints, Transcription Factors
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