Control of Excitatory and Inhibitory Synapse Formation by Neuroligins
Copyright policy )Control of Excitatory and Inhibitory Synapse Formation by Neuroligins
The normal function of neural networks depends on a delicate balance between excitatory and inhibitory synaptic inputs. Synapse formation is thought to be regulated by bidirectional signaling between pre- and postsynaptic cells. We demonstrate that members of the Neuroligin family promote postsynaptic differentiation in cultured rat hippocampal neurons. Down-regulation of neuroligin isoform expression by RNA interference results in a loss of excitatory and inhibitory synapses. Electrophysiological analysis revealed a predominant reduction of inhibitory synaptic function. Thus, neuroligins control the formation and functional balance of excitatory and inhibitory synapses in hippocampal neurons.
- King’s University United States
- University of Basel Switzerland
- Columbia University United States
Neurons, Cell Adhesion Molecules, Neuronal, Presynaptic Terminals, Action Potentials, Down-Regulation, Excitatory Postsynaptic Potentials, Membrane Proteins, Membrane Transport Proteins, Nerve Tissue Proteins, Neural Inhibition, Dendrites, Hippocampus, Cell Line, Rats, Mutation, Animals, Protein Isoforms, RNA Interference, Evoked Potentials, Cells, Cultured
Neurons, Cell Adhesion Molecules, Neuronal, Presynaptic Terminals, Action Potentials, Down-Regulation, Excitatory Postsynaptic Potentials, Membrane Proteins, Membrane Transport Proteins, Nerve Tissue Proteins, Neural Inhibition, Dendrites, Hippocampus, Cell Line, Rats, Mutation, Animals, Protein Isoforms, RNA Interference, Evoked Potentials, Cells, Cultured
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