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Amicoumacin A induces cancer cell death by targeting the eukaryotic ribosome

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 14 Jun 2016 France English Publisher:Springer Science and Business Media LLCJournal:Scientific Reports, volume 6 (eissn: 2045-2322,

Authors: Marat Yusupov; Gulnara Yusupova; Sergey E. Dmitriev; Sergey E. Dmitriev; Olga A. Dontsova; I. Prokhorova; Desislava S. Makeeva; +4 Authors

doi: 10.1038/srep27720

pmid: 27296282

pmc: PMC4906347

Amicoumacin A induces cancer cell death by targeting the eukaryotic ribosome

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Abstract

AbstractAmicoumacin A is an antibiotic that was recently shown to target bacterial ribosomes. It affects translocation and provides an additional contact interface between the ribosomal RNA and mRNA. The binding site of amicoumacin A is formed by universally conserved nucleotides of rRNA. In this work, we showed that amicoumacin A inhibits translation in yeast and mammalian systems by affecting translation elongation. We determined the structure of the amicoumacin A complex with yeast ribosomes at a resolution of 3.1 Å. Toxicity measurement demonstrated that human cancer cell lines are more susceptible to the inhibition by this compound as compared to non-cancerous ones. This might be used as a starting point to develop amicoumacin A derivatives with clinical value.

Country

France

Related Organizations

Russian Academy of Sciences
Russian Federation
Institut National de la Santé et la Recherche Médicale
France
Lomonosov Moscow State University
Russian Federation
University of Strasbourg
France
University of Strasbourg
France

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Keywords

Models, Molecular, Cell Death, Eukaryota, Saccharomyces cerevisiae, Crystallography, X-Ray, Article, [SDV] Life Sciences [q-bio], HEK293 Cells, Coumarins, Cell Line, Tumor, Protein Biosynthesis, Humans, RNA, Messenger, Ribosomes

77 Research products, page 1 of 8

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	51
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	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%