This paper presents the results of a study performed with a lab-scale dissolved-air flotation (LSDAF) unit fed with previously coagulated effluent from a pilot scale up-flow anerobic sludge blanket (UASB) reactor treating domestic sewage. Physical operational conditions for coagulation (rapid mix) and flocculation/flotation were maintained constant. Chemical (FeCl3) dosages ranged from 30 to 110 mg.l−1. The effect of pH was also verified in the range of 5.1 to 7.6 for each dosage. Best results were achieved for 65 mg.l−1 of FeCl3 and pH values between 5.3 and 6.1. For these conditions, the removal efficiencies obtained in the LSDAF unit were: between 87% and 91% for chemical oxygen demand (COD), between 95% and 96% for total phosphate (TP), 94% for total suspended solids (TSS), between 96% and 97% for turbidity (TU), between 90% and 93% for apparent color (AC) and more than 96% for sulfide (S). For the UASB-DAF system, global efficiencies would be around 98% for COD, 98% for TP, 98.4% for TSS, 99.3% for TU and 98% for AC. The stripped gases treatment is desirable.