In order to increase the efficiency of composting vinegar residue, the effect of different strain combination,a thermophiles(OP-2) and two rhizopus(FM1,SL10) combined,on the composting pocess and effect was studied. The results showed: Inoculating thermophilic bacteria OP-2 can increase the speed of composting vinegar residue, which can increase the heap temperature to 70°C in 7days ahead. Also inoculating inocula accelerated the mineralization of organic nitrogen. In the end of composting, the contents of total nitrogen、total phosphorus and total potassium, as well as GI were higher than the control treatment, which showed that inoculating inocula can accelerate the maturity process of composting vinegar residue and increase the composting quality.