The ARID domain of the H3K4 demethylase RBP2 binds to a DNA CCGCCC motif
Copyright policy )The ARID domain of the H3K4 demethylase RBP2 binds to a DNA CCGCCC motif
The histone H3 lysine 4 demethylase RBP2 contains a DNA binding domain, the AT-rich interaction domain (ARID). We solved the structure of ARID by NMR, identified its DNA binding motif (CCGCCC) and characterized the binding contacts. Immunofluorescence and luciferase assays indicated that ARID is required for RBP2 demethylase activity in cells and that DNA recognition is essential to regulate transcription.
- National Yang Ming University Taiwan
- The Ohio State University United States
- Academia Sinica Taiwan
- National Chiao Tung University Taiwan
Structure-Activity Relationship, Fluorescent Antibody Technique, Humans, Retinol-Binding Proteins, Cellular, DNA, Protein Serine-Threonine Kinases, Promoter Regions, Genetic, Nuclear Magnetic Resonance, Biomolecular, Protein Binding, Transcription Factors
Structure-Activity Relationship, Fluorescent Antibody Technique, Humans, Retinol-Binding Proteins, Cellular, DNA, Protein Serine-Threonine Kinases, Promoter Regions, Genetic, Nuclear Magnetic Resonance, Biomolecular, Protein Binding, Transcription Factors
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).104 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!