Wnt-3, a gene activated by proviral insertion in mouse mammary tumors, is homologous to int-1/Wnt-1 and is normally expressed in mouse embryos and adult brain.
Copyright policy )Wnt-3, a gene activated by proviral insertion in mouse mammary tumors, is homologous to int-1/Wnt-1 and is normally expressed in mouse embryos and adult brain.
We have isolated a common insertion site, Wnt-3, for proviruses of the mouse mammary tumor virus (MMTV). Of mammary tumors induced by the GR variant of MMTV, 5% contains a provirus at Wnt-3, which is located on mouse chromosome 11. The gene is transcribed into a 3.8-kilobase (kb) mRNA in tumors with nearby proviral insertions but not in tumors with proviruses at other loci or in most adult tissues. Normal expression of Wnt-3 is detected in mouse embryos (with a peak around day 12 of gestation) and at low levels in adult brain. The transcriptional unit of the Wnt-3 gene spans approximately 55 kb, with a first intron of 36 kb. The deduced amino acid sequence of the Wnt-3 protein is 47% identical to the int-1/Wnt-1 gene product.
- Netherlands Heart Institute Netherlands
- Antoni van Leeuwenhoek Hospital Netherlands
Gene Expression Regulation, Viral, Embryo, Nonmammalian, Base Sequence, Genes, Viral, Transcription, Genetic, Molecular Sequence Data, Restriction Mapping, Brain, Chromosome Mapping, Gene Expression, Mammary Neoplasms, Experimental, Proteins, Embryo, Mammalian, Mammary Tumor Virus, Mouse, Proviruses, Sequence Homology, Nucleic Acid, DNA, Viral, Animals, Amino Acid Sequence, Cloning, Molecular
Gene Expression Regulation, Viral, Embryo, Nonmammalian, Base Sequence, Genes, Viral, Transcription, Genetic, Molecular Sequence Data, Restriction Mapping, Brain, Chromosome Mapping, Gene Expression, Mammary Neoplasms, Experimental, Proteins, Embryo, Mammalian, Mammary Tumor Virus, Mouse, Proviruses, Sequence Homology, Nucleic Acid, DNA, Viral, Animals, Amino Acid Sequence, Cloning, Molecular
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