Microsatellite polymorphisms in the epidermal growth factor receptor (EGFR) gene and the transforming growth factor-?? (TGFA) gene and risk of oral cancer in Puerto Rico
Copyright policy )Microsatellite polymorphisms in the epidermal growth factor receptor (EGFR) gene and the transforming growth factor-?? (TGFA) gene and risk of oral cancer in Puerto Rico
Risks of oral cancer related to a CA microsatellite repeat polymorphism in intron 1 of the epidermal growth factor receptor (EGFR) gene and a TaqI polymorphism in the transforming growth factor-alpha (TGFA) gene were evaluated in a population-based case-control study consisting of 157 cases and 149 controls recruited in Puerto Rico.Carriers of > or = 16 CA repeats in EGFR showed a 1.9-fold increased risk for oral cancer (OR=1.9, 95% CI=1.0-3.5). Risks also tended to increase with decreasing number of alleles with > or = 16 CA repeats (P for trend=0.06). Our data suggested a non-significant reduction in risk for subjects heterozygous for the TGFA polymorphism (OR=0.6, 95% CI=0.2-1.3).The EGFR-associated risk appeared to be independent of tobacco and alcohol use and may be restricted primarily to subjects who consumed low amounts of fresh fruits and vegetables (OR=5.9, 95%CI: 2.3-15.2). These data implicate dietary and molecular targets for oral cancer prevention.
- Seoul National University Korea (Republic of)
- University of Puerto Rico System United States
- Rutgers, The State University of New Jersey United States
- National Institute of Health Pakistan
- New Generation University College Ethiopia
Adult, Male, Polymorphism, Genetic, Alcoholic Beverages, Puerto Rico, Smoking, Genes, erbB-1, Middle Aged, Transforming Growth Factor alpha, Risk Factors, Case-Control Studies, Fruit, Vegetables, Humans, Female, Mouth Neoplasms, Aged, Microsatellite Repeats
Adult, Male, Polymorphism, Genetic, Alcoholic Beverages, Puerto Rico, Smoking, Genes, erbB-1, Middle Aged, Transforming Growth Factor alpha, Risk Factors, Case-Control Studies, Fruit, Vegetables, Humans, Female, Mouth Neoplasms, Aged, Microsatellite Repeats
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