Phospholipase C-γ1 involved in brain disorders
Copyright policy )Phospholipase C-γ1 involved in brain disorders
Phosphoinositide-specific phospholipase C-γ1 (PLC-γ1) is an important signaling regulator involved in various cellular processes. In brain, PLC-γ1 is highly expressed and participates in neuronal cell functions mediated by neurotrophins. Consistent with essential roles of PLC-γ1, it is involved in development of brain and synaptic transmission. Significantly, abnormal expression and activation of PLC-γ1 appears in various brain disorders such as epilepsy, depression, Huntington's disease and Alzheimer's disease. Thus, PLC-γ1 has been implicated in brain functions as well as related brain disorders. In this review, we discuss the roles of PLC-γ1 in neuronal functions and its pathological relevance to diverse brain diseases.
- Pohang University of Science and Technology Korea (Republic of)
- UNIST (Ulsan National Institute of Science and Technology) Korea (Republic of)
- Ulsan National Institute of Science and Technology Korea (Republic of)
Neurons, Brain Diseases, Phospholipase C gamma, Brain-Derived Neurotrophic Factor, Brain, Synaptic Transmission, Gene Expression Regulation, Receptors, GABA, Humans, Receptor, trkB, Calcium, Nerve Growth Factors, Phosphorylation, gamma-Aminobutyric Acid, Signal Transduction
Neurons, Brain Diseases, Phospholipase C gamma, Brain-Derived Neurotrophic Factor, Brain, Synaptic Transmission, Gene Expression Regulation, Receptors, GABA, Humans, Receptor, trkB, Calcium, Nerve Growth Factors, Phosphorylation, gamma-Aminobutyric Acid, Signal Transduction
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