BindingDB Entry 50042698: Discovery of (1R,2R)-N-(4-(6-isopropylpyridin-2-yl)-3-(2-methyl-2H-indazol-5-yl)isothiazol-5-yl)-2-methylcyclopropanecarboxamide, a potent and orally efficacious mGlu5 receptor negative allosteric modulator.

Name: BindingDB Entry 50042698: Discovery of (1R,2R)-N-(4-(6-isopropylpyridin-2-yl)-3-(2-methyl-2H-indazol-5-yl)isothiazol-5-yl)-2-methylcyclopropanecarboxamide, a potent and orally efficacious mGlu5 receptor negative allosteric modulator.
Creator: BindingDB
Keywords: Metabotropic glutamate receptor, Metabotropic glutamate receptor 1, Metabotropic glutamate receptor 5, and Serotonin receptor (2b and 2c), Lilly Research Laboratories, Affinity, 3. Good health

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Dataset . 2013

Data sources: Datacite

BindingDB Entry 50042698: Discovery of (1R,2R)-N-(4-(6-isopropylpyridin-2-yl)-3-(2-methyl-2H-indazol-5-yl)isothiazol-5-yl)-2-methylcyclopropanecarboxamide, a potent and orally efficacious mGlu5 receptor negative allosteric modulator.

Research datakeyboard_double_arrow_right Dataset 01 Jan 2013 English Publisher:BindingDB

Authors: BindingDB;

doi: 10.7270/q2dj5h0z

BindingDB Entry 50042698: Discovery of (1R,2R)-N-(4-(6-isopropylpyridin-2-yl)-3-(2-methyl-2H-indazol-5-yl)isothiazol-5-yl)-2-methylcyclopropanecarboxamide, a potent and orally efficacious mGlu5 receptor negative allosteric modulator.

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Abstract

Small molecule binding data for protein Metabotropic glutamate receptor, Metabotropic glutamate receptor 1, Metabotropic glutamate receptor 5, and Serotonin receptor (2b and 2c), Uniprot P31424, P41594, P41595, and Q13255

Keywords

Metabotropic glutamate receptor, Metabotropic glutamate receptor 1, Metabotropic glutamate receptor 5, and Serotonin receptor (2b and 2c), Lilly Research Laboratories, Affinity

31 Research products, page 1 of 4

BindingDB Entry 50016697: Cyclohexenyl- and dehydropiperidinyl-alkynyl pyridines as potent metabotropic glutamate subtype 5 (mGlu5) receptor antagonists.
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Discovery of (1R,2R)-N-(4-(6-isopropylpyridin-2-yl)-3-(2-methyl-2H-indazol-5-yl)isothiazol-5-yl)-2-methylcyclopropanecarboxamide, a potent and orally efficacious mGlu5 receptor negative allosteric modulator
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