BindingDB Entry 50017775: Design and synthesis of noncompetitive metabotropic glutamate receptor subtype 5 antagonists.

Name: BindingDB Entry 50017775: Design and synthesis of noncompetitive metabotropic glutamate receptor subtype 5 antagonists.
Creator: BindingDB
Keywords: Metabotropic glutamate receptor and Metabotropic glutamate receptor 5, National Institute on Drug Abuse, Affinity

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Dataset . 2009

Data sources: Datacite

BindingDB Entry 50017775: Design and synthesis of noncompetitive metabotropic glutamate receptor subtype 5 antagonists.

Research datakeyboard_double_arrow_right Dataset 01 Jan 2009 English Publisher:BindingDB

Authors: BindingDB;

doi: 10.7270/q2rv0n9z

BindingDB Entry 50017775: Design and synthesis of noncompetitive metabotropic glutamate receptor subtype 5 antagonists.

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Abstract

Small molecule binding data for protein Metabotropic glutamate receptor and Metabotropic glutamate receptor 5, Uniprot P31424 and P41594

Keywords

Metabotropic glutamate receptor and Metabotropic glutamate receptor 5, National Institute on Drug Abuse, Affinity

30 Research products, page 1 of 3

BindingDB Entry 50048986: Positional isomers of bispyridine benzene derivatives induce efficacy changes on mGlu
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BindingDB Entry 50035348: [3H]-methoxymethyl-MTEP and [3H]-methoxy-PEPy: potent and selective radioligands for the metabotropic glutamate subtype 5 (mGlu5) receptor.
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BindingDB Entry 50028767: Structure-activity relationships comparing N-(6-methylpyridin-yl)-substituted aryl amides to 2-methyl-6-(substituted-arylethynyl)pyridines or 2-methyl-4-(substituted-arylethynyl)thiazoles as novel metabotropic glutamate receptor subtype 5 antagonists.
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BindingDB Entry 50015346: 2-(2-[3-(pyridin-3-yloxy)phenyl]-2H-tetrazol-5-yl) pyridine: a highly potent, orally active, metabotropic glutamate subtype 5 (mGlu5) receptor antagonist.
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BindingDB Entry 50015138: Discovery of novel heteroarylazoles that are metabotropic glutamate subtype 5 receptor antagonists with anxiolytic activity.
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BindingDB Entry 50041816: Hit-to-lead optimization of disubstituted oxadiazoles and tetrazoles as mGluR5 NAMs.
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BindingDB Entry 50049214: Discovery and Preclinical Characterization of 3-((4-(4-Chlorophenyl)-7-fluoroquinoline-3-yl)sulfonyl)benzonitrile, a Novel Non-acetylenic Metabotropic Glutamate Receptor 5 (mGluR5) Negative Allosteric Modulator for Psychiatric Indications.
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BindingDB Entry 6026: Substituted heteroarylamine carboxamide analogs as mGluR5 negative allosteric modulators and methods of making and using the same
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BindingDB Entry 50048025: Development of 1
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BindingDB Entry 50031369: Synthesis and SAR of novel, non-MPEP chemotype mGluR5 NAMs identified by functional HTS.
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