The rapid incidence of liver disorders is rampant in our society today and there is this very need to salvage the sudden and untimely death resulting from liver disorders. In this study, aqueous extract of Phoradendron leucarpum leaf was administered orally at doses of 50, 100 and 200 mg/kg body weight to wistar rats. Twenty (20) rats were divided into four groups of five in each group of which one group served as the control. The other groups were treated with the ethanolic leaf extract 50, 100, and 200 mg/kg of Phoradendron leucarpum (mistletoe). The extract was administered orally and the administration of the extract lasted for 21-days. Effect of the extract on liver function indices was assessed. Treatment of the rats with the ethanolic extract of Phoradendron leucarpum leaf showed significant (p<0.05) increase in liver biomarker enzymes activities in group IV animals fed with the extract only when compared to the control. There was no considerable increase in enzyme activities in group II and III animals compared with the control group. Hence, Phoradendron leucarpum leaf extract could possibly offer protective effects on liver cell membranes at considerably low concentration.