Introduction: A thrombosis is a blood clot in an artery that can be highly harmful because it stops blood from reaching essential organs. Arteries are blood vessels that convey blood from the heart to the rest of the body and the heart muscle. Clinical Finding: pain in left lower abdomen and as well as thoracic region also and pain in lower limb extremities are also occurred, pulse is 78 beats/ min, and temperature is 98.6°F or 37°. Diagnostic Evaluation: Blood test:- Hb –14.3 gm%, total RBC count – 4.84 millions/cu mm, RDW – 13.3%, HCT -42.4%, total WBC count –7100/cu mm, monocytes – 03%, granulocyte –70%, lymphocyte – 25%. Peripheral Smear: RBC:- normocytic normochromic, Platelets:- adequate on smear, No hemiparasite seen Ultrasonography: There is no sonography report founded. Therapeutic intervention: Inj. Ceftraxine- 19 mg, inj. Hydrotrsol – 100 mg, inj. Heparin – 5000 IV –TDS , tab. Ecosprin – 100 mg –OD, tab. Clopitab- 75 mg – OD. Outcome: After treatment, the patient has improved his fever, pain in the chest, and lower extremities pain have all been reduced. Conclusion: Patient was admitted to cardiology ward in hospital with known case of arterial thrombosis and he had complain of fever chest pain and also pain in lower limb. After getting appropriate treatment his condition was improved. Smoking, overweight, and drinking are additional factors that promote intra-arterial thrombosis. After getting therapy, patient's condition significantly improved, and the treatment was continue until final day of care.