The resident oral microbiota plays an important role as a factor in its colonization resistance that ensures human oral health. However, at the same time, oral microorganisms can act as causative agents of infectious diseases. Scientists emphasize that in the situation when bacteria demonstrated increased resistance to antibiotics, quorum sensing is a particularly attractive target, since this mechanism controls several factors of bacterial virulence that affect adhesion, invasion and colonization of microorganisms during the development of the pathological process. Quorum sensing inhibitors can be enzymes and various chemicals that able to affect quorum sensing. Streptococcus mitis is a representative of the resident microbiota of the human oropharynx. But despite its commensalism, Streptococcus mitis in association with other microorganisms takes part in many pathological processes. Objective of this study is to study the effect of Dekasan and Iodoform antiseptics on the adhesive properties of Streptococus mitis clinical isolates taken from the oral cavity of patients with infectious and inflammatory post-extraction complications. Materials and methods: examined clinical isolates of Streptococus mitis, which were isolated from 8 patients undergoing treatment for infectious-inflammatory post-extraction complications in the medical and surgical department of Poltava Regional Centre of Stomatology - Dental Clinical Polyclinic. Identification of selected cultures was carried out using an automatic bacteriological analyzer Vitec-2 compact bioMarieux (France). We used the average values of subbacteriostatic concentrations of the active ingredients of antiseptics. Adhesive properties of clinical isolates under the influence of Dekasan and Iodoform were determined according to the method of V.I. Brylis. Conclusions: antiseptics have different effects on the adhesive properties of clinical isolates of Streptococus mitis.