The article presents the results of the study of forensic effi cacy of diff erential diagnosis of alcohol and carbon monoxide poisoning, as well as establishing the age of death in these cases by diff use tomography of fl uctuations of linear fl uctuations of linear birefringence of human biological tissues. Aim of the work. Investigation of the eff ectiveness of the method of diff use tomography of biological products and polycrystalline blood fi lms in the forensic diff erential diagnosis of alcohol and carbon monoxide poisoning and determining the age of death in these cases.Materials and methods. The object of the study were histological samples of human internal organs (brain, myocardium) and polycrystalline blood fi lms in cases of death from ethanol poisoning, carbon monoxide and coronary heart disease (control group) with diff erent ages (6 to 48 hours). The study was performed using the method of diff use tomography of fl uctuations in the parameters of optical anisotropy of layers of biological tissues and fl uids.Results. The eff ectiveness of analytical determination of the age of death in cases of ethanol and carbon monoxide poisoning by analyzing the range of linear changes in the magnitude of statistical moments of 1-4 orders of magnitude, ranging from 24 to 60 hours. The accuracy of determining the age of death is 0.5 hours.Conclusion. The eff ectiveness of the method of diff use tomography of fl uctuations of linear birefringence of layers of biological tissues and fl uids in diff erentiating the cause of death in cases of ethanol and CO poisoning, as well as diagnosing the age of death in these cases.