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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Gynecologic and Obst...arrow_drop_down
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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Germline <b><i>BRCA</i></b> Mutation Rates in Latina Women Presenting for Gynecologic Oncology Care

Authors: Linda Hong; Rebecca Gonzalez; Julia Unternaehrer; Yevgeniya Ioffe;

Germline <b><i>BRCA</i></b> Mutation Rates in Latina Women Presenting for Gynecologic Oncology Care

Abstract

<b><i>Objective:</i></b> Germline <i>BRCA</i> mutation rates in the Latina population are yet to be well described. We aimed to quantitate the rates of referral for genetic testing in qualifying women and testing completion rates in a population of women presenting for gynecologic oncology care. Results were then stratified by ethnic/racial background. <b><i>Methods:</i></b> Charts of new patients evaluated at a comprehensive cancer center in Southern California were reviewed. Patients qualifying for genetic testing in accordance with NCCN Guidelines version 1.2017 for breast and/or ovarian cancer genetic assessment were identified. The actual rates of prescriptions for genetic testing placed, testing completion rates, test results, as well as patients’ family history were abstracted. Data were analyzed with chi-square tests. <b><i>Results:</i></b> Five hundred and seventy-two of 2,053 patients met testing criteria, and 256/572 (45%) were prescribed testing in accordance with the guidelines. By ethnicity, testing was prescribed in 44% of Non-Hispanic White (NHW), 44% of Latina, 46% of African-American, and 60% of Asian (<i>p</i> = 0.6) patients. Testing was completed in 65% of NHW, 66% of Latina, 65% of African-American, and 67% of Asian patients (<i>p</i> = 0.97). Completion rates were low overall: 28% of those who met testing criteria were tested (<i>p</i> = 0.85). Pathogenic <i>BRCA</i> mutations were found in 29% of NHW and 21% of Latina, 45% of African-American, and 20% of Asian patients (<i>p</i> = 0.4). <b><i>Conclusions:</i></b> There was no difference by ethnicity in rates of testing prescription, completion, or presence of <i>BRCA</i> mutations. Overall, testing rates were suboptimal. <i>BRCA</i> mutations were found in large percentage of Latinas (21%). Further studies are underway to identify barriers to testing prescriptions and completion for Latina women.

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
2
Average
Average
Average
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