OBJECTIVE: To validate the usability of “Beksaç Obstetrics Index” (BOI/BOIp) in the evaluation of different high risk pregnancy groups. STUDY DESIGN: This study is consisted of 3 groups of patients; 1) Pregnancies without MTHFR polymorphisms (n=65), 2) Pregnancies with methylenetetrahydrofolate reductase (MTHFR; homozygous or compound heterozygous) polymorphisms (n=140), 3) Pregnancies with “autoimmune antibody positivity” without any other type of hereditary thrombophilia (Anti-dsDNA, anti-phospholipid Ig G/M, anti-cardiolipin Ig G/M, ASMA, APA, ENA, anti-mitochondrial antibodies) (n=76). In this study, BOI which is (number of child +π/10)/Gravida is used in order to demonstrate the risk levels/scale of different high risk pregnancy groups. RESULTS: The mean BOIp (±SD) values are 0,41±0,22; 0,29±0,21; and 0,40±0,23 for Control, MTHFR and Autoimmune groups respectively. We have demonstrated statistically significantly decreased BOIp level in MTHFR group compared to the other groups (p:0,002). CONCLUSION: We have demonstrated that BOI/BOIp can be used in the assessment of risk levels of different high risk pregnancy groups.