Changes in the rheological properties of the blood in patients with psoriasis is manifested by increased performance of the surface elasticity, bulk viscosity and integral angular viscoelasticity on the background of reduced angulation of tensiorheogram, interrelated with integral chan­ges in surfactant system of the blood and its components (total protein, albumin, fibrinogen, fibronectin, C-reactive protein, ­β2-microglobulin, immunoglobulin G, total lipids, cholesterol, triglycerides, low density lipoproteins, apolipoproteins B), indicators of which depend on the form of skin psoriasis, presence of tendovaginitis, the degree of disease activity and the nature of joint syndrome, and an imbalance of protein-lipid surfactant complex of the body of patients can be detec­ted by the parameters of bulk viscosity and angulation of tensiorheogram.