Powered by OpenAIRE graph
Found an issue? Give us feedback
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Revista Portuguesa d...arrow_drop_down
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
Revista Portuguesa de Pneumologia
Article . 2003
Data sources: DOAJ
addClaim

This Research product is the result of merged Research products in OpenAIRE.

You have already added 0 works in your ORCID record related to the merged Research product.

36. Diagnóstico do cancro do pulmão: comparação da expectoração pósbroncoscopia, lavado, escovado e biópsia brônquicos

Authors: Adelina Amorim; Elena Lombardia; Maria Sucena; Gabriela Fernandes; Adriana Magalhães;

36. Diagnóstico do cancro do pulmão: comparação da expectoração pósbroncoscopia, lavado, escovado e biópsia brônquicos

Abstract

O cancro do pulmão é uma das doenças respiratórias mais importantes. A broncofibroscopia (BRF) é um exame largamente utilizado no seu diagnóstico e estadiamento e, em casos específicos, no seu tratamento. São várias as técnicas broncoscópicas actualmente usadas com fim diagnóstico. As mais comummente aplicadas são o lavado (LB), o escovado (EB) e a biópsia (BB) brônquicos.Foi objectivo deste trabalho avaliar a rentabilidade diagnóstica destas três técnicas, bem como da citologia da expectoração pósbroncoscopia (EPB), na presença de lesão endoscópica visível suspeita de neoplasia pulmonar.De Setembro de 2001 a Fevereiro de 2003 foram realizadas 56 broncofibroscopias em doentes com história clínica e lesão endoscópica sugestiva de cancro do pulmão (hiperemia/infiltração/ massa), as quais incluíram sempre a execução de LB, EB e BB. Sempre que possível procedeu-se à colheita de EPB. Foram excluídos os doentes em que não se obteve diagnóstico de malignidade por nenhuma das 4 técnicas aplicadas. Os resultados foram classificados como positivos, negativos ou suspeitos de malignidade.O diagnóstico de cancro de pulmão, através de pelo menos uma das três técnicas broncoscópicas ou EPB, foi efectuado em 44 doentes (78,6%). No total destes doentes a rentabilidade diagnóstica do LB foi de 56,8%, a do EB de 79,5%, a da BB de 95,5%. A rentabilidade da EPB foi de 28,6% (n=42).As três técnicas foram simultaneamente positivas para malignidade em 52,3% do total, sendo concordantes em termos de especificação do tipo de histológico em 69,6%. O EB e a BB foram ambos positivos em 22,8% (concordância de 70%) e o LB e BB em 4,5% (concordância de 100%). O EB foi a única técnica diagnóstica positiva em 4,5% dos casos e a BB em 15,9%. O LB e a EPB nunca foram o único resultado positivo.Dos 7 casos em que o EB foi positivo para malignidade mas não permitiu a especificação do tipo histológico, 5 (71,4%) foram esclarecidos pela BB. Por sua vez, dos 7 casos em que a BB não foi esclarecedora do tipo específico de cancro, 3 foram definidos pelo EB (42,9%).Quanto ao aspecto endoscópico foram descritos 63,4% casos de infiltração e os restantes de massa. O LB foi mais frequentemente positivo na presença de infiltração comparativamente a massa (64% vs 36%). Não se verificaram diferenças significativas em relação ao EB e à BB.Continua a existir na literatura alguma controvérsia quanto ao valor diagnóstico do LB, EB, BB e EPB no cancro do pulmão. Este trabalho mostra claramente que a BB é a técnica mais rentável, sendo também consideráveis os valores obtidos para o LB e EB. No entanto, é de realçar que o LB e a EPB não constituíram em nenhum caso a única técnica diagnóstica positiva para malignidade, nem contribuíram para o esclarecimento do tipo histológico em causa. A realização de EB apenas aumentou em 3,5% a rentabilidade diagnóstica total. : Lung cancer is one of the most important respiratory diseases. The flexible bronchoscopy (FBC) is an exam widely used in its diagnosis and staging and, in specific cases, its treatment. There are several diagnostic bronchoscopies techniques currently used. The most common are the bronchial washing (BW), brushing (BBR) and biopsy (BB).It was our aim to evaluate the diagnostic yield of these three techniques, as well as, the post-bronchoscopy sputum cytology (PBSC), at presence of a suspicious visible endoscopy lesion of lung cancer. From September of 2001 to February of 2003, 56 FBC were carried out on patients with clinical history and suggestive endoscopy injury of lung cancer (hyperaemia/infiltration/tumour). In all patients we performed BW, BBR and BB and, always if it was possible, PBSC. The patients were excluded when the 4 applied diagnostic techniques were negative for malignancy. The results had been classified as positive, negative or suspected.The diagnosis of lung cancer, through at least one of three bronchoscopies techniques or PBSC, was obtained in 44 patients (78,6%). In the total of these patients the diagnostic yield from BW was 56,8%, from BBR 79,5%, from BB 95,5%. The yield from PBSC was 28,6% (n=42). The three techniques were simultaneously positive for malignancy in 52,3% of the total, being concordant, in terms of specification of the histologic type, in 69,6%. The BBR and the BB were both positive in 22,8% (70% agreement) and BW and BB in 4,5% (100% agreement). The BBR was the only positive diagnostic technique in 4,5% of the cases and the BB in 15,9%. The BW and the PBSC were never the only positive result.Of the 7 cases where the BBR was positive for malignancy but did not allow the specification of the histology type, 5 (71, 4%) were clarified by the BB. In turn, of the 7 cases where the BB was not diagnostic of the specific type of cancer, 3 were defined by BBR (42,9%).The endoscopy aspect had been described as infiltration in 63.4% cases and the remaining as tumour. The BW was more frequently positive in presence of infiltration in comparison to tumour (64% versus 36%). It were not verified significant differences in relation to the BBR and BB.In literature there continues to exist some controversy about the diagnostic value of the BW, BBR, BB and PBSC in lung cancer. This work clearly shows that the BB is the most cost-effective technique, but the values obtained for BW and BBR were also relevant. However, it is to be stressed that neither the BW nor the PBSC constituted at any time the only positive diagnostic technique for malignancy, neither did they contributed for the clarification of the histologic type. The BBR only increased by 3,5% the total diagnostic yield. Palavras-chave: Lavado, escovado e biópsia brônquicos, rentabilidade diagnóstica, cancro do pulmão, key-words: bronchial washing, brushing and biopsy, diagnostic yield, lung cancer

Keywords

Diseases of the respiratory system, RC705-779

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    0
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
Powered by OpenAIRE graph
Found an issue? Give us feedback
selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
gold
Related to Research communities
Cancer Research