Aim. To assess effectiveness, safety, cognitive and emotional effects of amlodipine as monotherapy and in combination with thiazide diuretic in middle-aged women with mild to moderate arterial hypertension (AH). Material and methods. The study included 30 women aged 35-50 years with Stage I-II AH, receiving amlodipine monotherapy (2,5-5 mg/d, with dose titration to 10 mg/d), and in combination, if needed, with hypothiazide (25 mg/d). Cognitive function and emotional status were assessed by correcting test, number sorting test, Hospital Anxiety and Depression Scale (HADS), and Taylor anxiety scale. Results. In 96,4% of the patients, amlodipine therapy resulted in reaching target blood pressure (BP) levels, and monotherapy was effective in 67,8% of the cases. Amlodipine and hypothiazide combination was necessary for 28,6% of the patients. Treatment was associated with significant improvement in attention concentration parameters, decreased levels of anxiety and depression, as well as high treatment compliance and low adverse event rates. Conclusion. Amlodipine is effective for BP control, being also characterized by beneficial influence on psychoemotional status and by high treatment compliance.