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Croatian Scientific Bibliography - CROSBI
Article . 2004
Data sources: Croatian Scientific Bibliography - CROSBI
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A functional cytochrome P450 lanosterol 14α -demethylase CYP51 enzyme in the acrosome: transport through the Golgi and synthesis of meiosis-activating sterols.

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2004 Croatia English
Authors: Cotman, Marko; Ježek, Davor; Fon Tacer Klementina; Frangež, R; Rozman, Damjana;

A functional cytochrome P450 lanosterol 14α -demethylase CYP51 enzyme in the acrosome: transport through the Golgi and synthesis of meiosis-activating sterols.

Abstract

Mammalian lanosterol 14a-demethylase (CYP51) is a microsomal cytochrome P450 that demethylates lanosterol to FFMAS, an oocyte meiosis-activating sterol and late intermediate of cholesterol biosynthesis. Herein we report CYP51 unequivocally localized to acrosomal membranes of male germ cells in mouse, bull, and ram, in which it synthesizes FF-MAS in the presence of the acrosomal form of nicotinamide adenine dinucleotide phosphate reduced-P450 reductase. In the mouse, CYPS1 (53 kDa) resides in endoplasmic reticulum (ER) and Golgi during all phases of acrosome development, indicating an intracellular transport irom ERs through the Golgi to the acrosome. CYPS1 (50 kDa) also resides on acrosomal membranes of bull- and ram-ejaculated sperm.

Country
Croatia
Keywords

CYP51; meiosis-activating sterol; Golgi apparatus

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
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