To explore the clinical effectiveness and value of lacrimal duct endoscopy in lacrimal canaliculitis and nasolacrimal duct obstruction diseases.We retrospectively analyzed 241 patients with lacrimal canaliculitis and nasolacrimal duct obstructions admitted to our hospital from January 2019 to June 2020. Among them, 165 patients underwent routine diagnosis and treatment and 76 patients underwent lacrimal duct endoscopy. The propensity score matching 1:1 nearest neighbor matching method was used to match 50 patients from each of the two methods to create a control group and an experimental group, respectively. We compared the two groups' effective treatment rates, incidences of adverse reactions, diagnostic accuracy, and IL-6, IL-8, and CRP expression levels.in contrast with the control group, we observed a significantly higher effective treatment rate in the experimental group (P<0.05). The experimental group had a significantly better reactions rate than the control group (P<0.05). In terms of the diagnostic accuracy rate, the experimental group's results were much better (P<0.05). The IL-6, IL-8, and CRP expression levels in the experimental group were much lower in the comparison with the control group (P<0.05).Lacrimal duct endoscopic diagnosis and treatment can significantly enhance the treatment efficiency and diagnostic accuracy in lacrimal canaliculitis and nasolacrimal duct obstruction patients and can help reduce adverse reactions and the IL-6, IL-8, and CRP expression levels during the treatment. Therefore, lacrimal duct endoscopy has a high clinical effectiveness in lacrimal canaliculitis and nasolacrimal duct obstruction patients.