Depending on the route of infection, experimental exposure of 30 sheep to Corynebacterium pseudotuberculosis resulted in either mucopurulent vaginitis, prosthitis, conjunctivitis, rhinitis, or in subcutaneous abscessation. Caseous lymphadenitis, from which the organism could be recovered in 52 out of 56 instances, occurred in every instance with the exception of animals infected by the preputial route.