[(A1-beta-Alanine) insulin].

descriptionPublicationkeyboard_double_arrow_right Article 28 Jan 1977 German Journal:Hoppe-Seyler's Zeitschrift fur physiologische Chemie, volume 357 (issn: 0018-4888,

Authors: R, Geiger; K, Geisen; G, Regitz; H D, Summ;

pmid: 992580

[(A1-beta-Alanine) insulin].

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Abstract

Starting from porcine insulin, A1-glycine was substituted by beta-alanine. The blood sugar lowering effect of the new analogue in the rabbit is about 45% of that of insulin. The half-maximal binding to partially purified rat liver receptors is about 46%, to transformed human lymphocytes about 54%, compared to insulin.

Keywords

Blood Glucose, Alanine, In Vitro Techniques, Rats, Liver, Animals, Humans, Insulin, Lymphocytes, Rabbits, Protein Binding

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