KAPOSI'S DISEASE: HHV-8 sequences have been found in all the epidemiological forms of Kaposi's disease. There is a direct relationship between HHV-8 infection and PBMC and later development of Kaposi's disease. The HHV-8 sequences can be found in spindle cells or endothelial cells in Kaposi lesions. OTHER DISEASES: HHV-8 is also associated with certain lymphomas including body-cavity-based lymphomas and Castleman's disease. It has also been put forward that there is a relationship between HHV-8 and multiple myeloma, epithelial tumors in kidney transplant recipients, angiosarcoma, and angiolymphoid hyperplasia.