[Growth hormone treatment of familial hypophosphatemic rickets].
Copyright policy )[Growth hormone treatment of familial hypophosphatemic rickets].
X-linked hypophosphatemic rickets (XLHR) is frequently associated with growth retardation and short adult stature, even with an appropriate conventional treatment associating phosphate and calcitriol or 1 alpha-hydroxyvitamin D. Its pathogenesis is unclear; growth hormone (GH) secretion is usually normal. Six children with XLHR and growth retardation were treated with GH during 6 years. In addition, they received the conventional treatment. At the beginning of the treatment mean age was 7.8 +/- 1.8 years, and height mean Z score was -3.4 +/- 0.5. A control group was composed of six children with XLHR (age: 7.9 +/- 2.5 years) receiving the conventional treatment only. Under GH treatment statural growth was improved, with significant increase in Z score and predicted adult height; the height gain was significantly higher in the GH treated group as compared with the group receiving the conventional treatment only. In addition, radial bone mineral density increased significantly under GH treatment. GH treatment thus appears to be a useful treatment to improve statural growth in children with XLHR.
- University of Pisa Italy
Adult, Male, Body Height, Phosphates, Treatment Outcome, Calcitriol, Bone Density, Growth Hormone, Humans, Drug Therapy, Combination, Female, Child, Growth Disorders, Hypophosphatemia, Familial, Cholecalciferol, Follow-Up Studies
Adult, Male, Body Height, Phosphates, Treatment Outcome, Calcitriol, Bone Density, Growth Hormone, Humans, Drug Therapy, Combination, Female, Child, Growth Disorders, Hypophosphatemia, Familial, Cholecalciferol, Follow-Up Studies
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).8 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!