[Transport into the cell nucleus of p42 and p44 isoforms of MAP kinase induced by epidermal growth factor requires the presence of intact active cytoskeleton].
Copyright policy [Transport into the cell nucleus of p42 and p44 isoforms of MAP kinase induced by epidermal growth factor requires the presence of intact active cytoskeleton].
The influence of cytoskeleton-depolymerising agents (nocodazole and cytochalasine D) on EGF-induced transport of p42/p44MAPK into the cell nucleus was investigated. Using immunoblotting and immunofluorescence methods we have shown that depolymerization of microtubules does not affect EGF-induced nuclear import of MAPK, while actin depolymerization significantly inhibited this process. At the same time, cytochalasine D did not affect the EGF-induced MAPK activation in the cytoplasm. These data indicate that the EGF-induced nuclear import of MAPK depends on the microfilament system.
- Institute of Cytology Russian Federation
Cell Nucleus, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase 3, Epidermal Growth Factor, Biological Transport, 3T3 Cells, Mice, Calcium-Calmodulin-Dependent Protein Kinases, Animals, Humans, Mitogen-Activated Protein Kinases, Cytoskeleton
Cell Nucleus, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase 3, Epidermal Growth Factor, Biological Transport, 3T3 Cells, Mice, Calcium-Calmodulin-Dependent Protein Kinases, Animals, Humans, Mitogen-Activated Protein Kinases, Cytoskeleton
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