[Histone deacetylase and retinoblastoma protein].
Copyright policy )[Histone deacetylase and retinoblastoma protein].
The balance between cellular proliferation and differentiation is strictly controlled in the cell and the deregulation of this balance can lead to tumour formation. The tumour suppressor protein Rb plays a key role in this balance essentially by repressing progression through the cell cycle and thereby it blocks the cell in G1 phase. Rb represses S phase genes through the recruitment of an enzyme which modifies DNA structure, the histone deacetylase HDAC1. The Rb/HDAC1 complex is a key element in the control of cell proliferation and differentiation. Moreover, this complex is likely to be a target for transforming viral proteins.
Cell Cycle, Cell Cycle Proteins, Cell Differentiation, Histone Deacetylase 1, Oncogene Proteins, Viral, Retinoblastoma Protein, Histone Deacetylases, E2F Transcription Factors, S Phase, DNA-Binding Proteins, Humans, Adenovirus E1A Proteins, Phosphorylation, Carrier Proteins, Papillomaviridae, Transcription Factor DP1, Retinoblastoma-Binding Protein 1, Transcription Factors
Cell Cycle, Cell Cycle Proteins, Cell Differentiation, Histone Deacetylase 1, Oncogene Proteins, Viral, Retinoblastoma Protein, Histone Deacetylases, E2F Transcription Factors, S Phase, DNA-Binding Proteins, Humans, Adenovirus E1A Proteins, Phosphorylation, Carrier Proteins, Papillomaviridae, Transcription Factor DP1, Retinoblastoma-Binding Protein 1, Transcription Factors
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