Genetic medicines including antigen, antisense molecules, ribozymes, aptamers, plasmid, gene have been enthusiastically studied as pharmaceutical agents. In the past decade, genetic medicines have been bogged down in solving serious problems, especially delivery efficiency. Steady study are continued to apply chemical modifications, cationic liposomes or another drug carriers enhance biological activities of genetic medicines. At this current moment, some of them have been carried on in clinical stages, which are intriguing to keep attention on the results coming soon. In this review, we address the current trends in genetic medicines especially antisense oligonucleotides and aptamers.