[Preparation and properties of monoclonal antibodies to tick-borne encephalitis viral nonstructural proteins].

V A, Matveeva; E Iu, Dobrikova; N A, Tsekhanovskaia; R V, Popova; E K, Pressman; A S, Karavanov; L E, Matveev

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Article . 1998

Data sources: Europe PubMed Central

[Preparation and properties of monoclonal antibodies to tick-borne encephalitis viral nonstructural proteins].

descriptionPublicationkeyboard_double_arrow_right Article 22 Sep 1998 Russian Journal:Voprosy virusologii, volume 43 (issn: 0507-4088,

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Authors: V A, Matveeva; E Iu, Dobrikova; N A, Tsekhanovskaia; R V, Popova; E K, Pressman; A S, Karavanov; L E, Matveev;

pmid: 9702814

[Preparation and properties of monoclonal antibodies to tick-borne encephalitis viral nonstructural proteins].

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Abstract

Hybridomas secreting monoclonal antibodies (Mab) to tick-borne encephalitis (TBE) virus are obtained. Immunodiffusion showed that 3 Mabs to TBE protein NS3 belong to class IgM and the rest to IgG1. Mabs to TBE protein NS1 were tested in hemagglutination inhibition, complement fixation, neutralization, and protection tests. Only 1 hybridoma produced Mab specific for protein NS1 of TBE strain Sofyin, the rest reacted with the common antigenic determinants of nonstructural TBE complex.

Keywords

Immunodiffusion, Mice, Inbred BALB C, Hybridomas, Viral Proteases, Serine Endopeptidases, Antibodies, Monoclonal, Viral Nonstructural Proteins, Nucleoside-Triphosphatase, Encephalitis Viruses, Tick-Borne, Immunoenzyme Techniques, DEAD-box RNA Helicases, Mice, Animals, Humans, RNA Helicases

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