[Mycophenolate mofetil].
Copyright policy )[Mycophenolate mofetil].
Mycophenolate Mofetil (MMF) is a new immunosuppressive agent that selectively inhibits the proliferation of T and B lymphocytes. The use of MMF in renal transplantation significantly reduced the incidence of acute rejection episodes in the first year after transplantation. The main toxicities of MMF are the occurrence of diarrhea and leucopenia. This potent immunosuppressive agent is devoid of the nephrotoxicity of cyclosporin and of the multiple adverse effects of corticosteroids. Clinical trials are currently in progress to assess whether the use of MMF will allow the discontinuation of cyclosporine or corticosteroid therapy without leading to an increased risk of rejection. If results were positive, MMF would represent a significant advance in the field of renal transplantation.
- Université Libre de Bruxelles Belgium
- Vrije Universiteit Brussel Belgium
Diarrhea, Graft Rejection, kidney, T-Lymphocytes, kidney transplantation, Kidney Transplantation -- immunology, Graft Rejection -- prevention & control, Kidney, B-Lymphocytes -- drug effects, Adrenal Cortex Hormones, Risk Factors, Journal Article, risk factors, Humans, Adrenal Cortex Hormones -- adverse effects, Cell Division -- drug effects, Mycophenolic acid, B-Lymphocytes, Clinical Trials as Topic, T-Lymphocytes -- drug effects, Incidence, Cyclosporine -- adverse effects, Leukopenia, Sciences bio-médicales et agricoles, Immunosuppressive Agents -- adverse effects -- therapeutic use, Mycophenolic Acid, Kidney Transplantation, Acute Disease, incidence, Cyclosporine, Leukopenia -- chemically induced, Kidney -- drug effects, Mycophenolic Acid -- adverse effects -- analogs & derivatives -- therapeutic use, Cell Division, Immunosuppressive Agents, Diarrhea -- chemically induced
Diarrhea, Graft Rejection, kidney, T-Lymphocytes, kidney transplantation, Kidney Transplantation -- immunology, Graft Rejection -- prevention & control, Kidney, B-Lymphocytes -- drug effects, Adrenal Cortex Hormones, Risk Factors, Journal Article, risk factors, Humans, Adrenal Cortex Hormones -- adverse effects, Cell Division -- drug effects, Mycophenolic acid, B-Lymphocytes, Clinical Trials as Topic, T-Lymphocytes -- drug effects, Incidence, Cyclosporine -- adverse effects, Leukopenia, Sciences bio-médicales et agricoles, Immunosuppressive Agents -- adverse effects -- therapeutic use, Mycophenolic Acid, Kidney Transplantation, Acute Disease, incidence, Cyclosporine, Leukopenia -- chemically induced, Kidney -- drug effects, Mycophenolic Acid -- adverse effects -- analogs & derivatives -- therapeutic use, Cell Division, Immunosuppressive Agents, Diarrhea -- chemically induced
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