[Transformation of serum immunoglobulins and monoclonal antibodies into polyreactive immunoglobulins].
Copyright policy )[Transformation of serum immunoglobulins and monoclonal antibodies into polyreactive immunoglobulins].
It was shown that polyreactive properties of natural serum immunoglobulins or some monoclonal antibodies (i.e. their ability of binding to various antigenically dissimilar antigens) can be induced by the treatment with chaotropic ions (3.5 M KSCN, 5-30 min at 20 (C). Such transformation of monoclonal antibodies or serum immunoglobulins into polyreactive immunoglobulins (PRIG) seems to result of the changes in immunoglobulin conformation but is not from their unblocking. Interaction of PRIG with some antigens immobilized on the plate is strongly dependent on temperature unlike that of monospecific antibodies.
Antibody Specificity, Protein Conformation, Animals, Antibodies, Monoclonal, Humans, Immunoglobulins, Rabbits, Adaptation, Physiological
Antibody Specificity, Protein Conformation, Animals, Antibodies, Monoclonal, Humans, Immunoglobulins, Rabbits, Adaptation, Physiological
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).0 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!