Expression of antimetastatic gene nm23-H1 in epithelial ovarian cancer.
Copyright policy )Expression of antimetastatic gene nm23-H1 in epithelial ovarian cancer.
To investigate the expression of nm23-H1 in epithelial ovarian cancer.A total of 55 specimens from patients with epithelial ovarian cancers, 15 patients with serous cancers, 7 with mucinous cancers, 17 with endometrioid cancers and 16 with adenocarcinomas, were examined for the expression of nm23-H1 by means of the immunohistochemical technique.The total positive rate was 23.64% (13/55). The tissular nm23-H1 immunostaining had significantly higher expression in mucinous cancer (57.14%) than in other histologic types of epithelial ovarian cancer (P < 0.05). Compared to that in the primary tumor, nm23-H1 expression in the omental metastatic tumor in the same patient was reduced.The expression rate of nm23-H1 is higher in the primary tumors than in the metastatic tumors and is different in various histologic subtypes of epithelial ovarian cancer. The expression of nm23-H1 may participate in the inhibitory process of tumor invasion.
- Obstetrics and Gynecology Hospital of Fudan University China (People's Republic of)
Ovarian Neoplasms, Gene Expression, Adenocarcinoma, NM23 Nucleoside Diphosphate Kinases, Cystadenocarcinoma, Mucinous, Cystadenocarcinoma, Serous, Lymphatic Metastasis, Nucleoside-Diphosphate Kinase, Humans, Female, Genes, Tumor Suppressor, Carcinoma, Endometrioid, Monomeric GTP-Binding Proteins, Transcription Factors
Ovarian Neoplasms, Gene Expression, Adenocarcinoma, NM23 Nucleoside Diphosphate Kinases, Cystadenocarcinoma, Mucinous, Cystadenocarcinoma, Serous, Lymphatic Metastasis, Nucleoside-Diphosphate Kinase, Humans, Female, Genes, Tumor Suppressor, Carcinoma, Endometrioid, Monomeric GTP-Binding Proteins, Transcription Factors
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).4 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!