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A convenient and efficient synthesis of sialyl Lewis X.

descriptionPublicationkeyboard_double_arrow_right Article 27 May 1998 English Journal:Bioscience, biotechnology, and biochemistry, volume 62 (issn: 0916-8451, Copyright policy )
Authors: K, Baba; N, Iwata; H, Hamajima; T, Ikami; H, Ishida; A, Hasegawa; M, Kiso;

pmid: 9571794

A convenient and efficient synthesis of sialyl Lewis X.

Abstract

A convenient synthesis of the sialyl Lewis X (sLe(x)) tetrasaccharide, NeuAc alpha 2-3Gal beta 1-4(Fuc alpha 1-3)GlcNAc (8), as a carbohydrate ligand for selectins is described. The key step is the reaction between NeuAc alpha 2-3GalSMe (5) as a glycosyl donor and the suitably protected Fuc alpha 1-3GlcNAc derivative (4) as the glycosyl acceptor by using dimethyl(methylthio)sulfonium triflate (DMTST) as the promoter.

Keywords

Glycosylation, Carbohydrate Sequence, Molecular Sequence Data, Oligosaccharides, Sialyl Lewis X Antigen

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
4
Average
Average
Average
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