
Effect of oxyfedrine (OXF)(1 mg/kg) administered just before reperfusion (post-treatment) was investigated in a canine model of myocardial stunning. In the saline-treated animals, myocardial stunning was evidenced by fall in MAP, decrease in LV peak (+) dP/dt, rise in LVEDP and incomplete regeneration of myocardial ATP, after reperfusion. OXF was found to be effective in preventing the haemodynamic and metabolic changes associated with myocardial stunning.
Myocardial Stunning, Cardiotonic Agents, Dogs, Myocardium, Hemodynamics, Animals, Heart, Oxyfedrine
Myocardial Stunning, Cardiotonic Agents, Dogs, Myocardium, Hemodynamics, Animals, Heart, Oxyfedrine
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