[GM1-gangliosidosis knockout mouse].

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1998 Japanese Publisher:THE JAPANESE SOCIETY OF CHILD NEUROLOGYJournal:No to hattatsu = Brain and development, volume 30 (issn: 0029-0831,

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Authors: Oshima, Akihiro;

pmid: 9545780

[GM1-gangliosidosis knockout mouse].

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Abstract

We generated a beta-galactosidosis mouse by gene targeting in an embryonic stem cell. Clinical, pathological, and biochemical analyses revealed that this mouse is a useful animal model to study the pathogenesis and therapy of human GM1-gangliosidosis.

Related Organizations

National Institute of Infectious Diseases
Japan

Keywords

Mice, Knockout, Gangliosidosis, GM1, Genetic Therapy, beta-Galactosidase, β-ガラクトシダーゼ, Disease Models, Animal, Mice, 遺伝子治療, Animals, Humans, ノックアウトマウス, G<SUB>M1</SUB>-ガングリオシドーシス

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