Knowing about the rate of tuberculous infection and disease in prison population and workers in Huelva prison, and the association of tuberculosis with the sociosanitary risk factors.Descriptive research for a year in 141 male prisoners at the age of 20 to 52 years old, from the 1sT of February in 1994 to the 1sT in 1995.The prevalence on tuberculous infection is 46.4% (accumulative incidence); and tuberculous disease 3.5% (accumulative incidence 1.4%) on the prisoners and the prevalence on tuberculous infection on the prison officers is 18.8% (there wasn't incidence) and the was no disease.It's perceived a high rate of tuberculous disease on the prisoners at the expense of people with infection by HIV and drugs addicts by parenteral way. The socio-cultural variables affect the tuberculous infection and disease tuberculous.