Pre-TCR/CD3 and TCR/CD3 complexes: decamers with differential signalling properties?
Copyright policy )Pre-TCR/CD3 and TCR/CD3 complexes: decamers with differential signalling properties?
Currently, the favoured model for the structure of the T-cell receptor (TCR)/CD3 complex proposes a monovalent TCR alpha beta/CD3 gamma epsilon delta epsilon zeta zeta octameric complex. However, other biochemical, structural and functional data point to a bivalent (TCR alpha beta)2/CD3 gamma epsilon delta epsilon zeta zeta decameric organization, which has a favourable neutral transmembrane net charge within the complex. Here, Heinz Jacobs proposes a model for the organization of the pre-TCR and discusses its function in signal transduction.
Major Histocompatibility Complex, CD3 Complex, Models, Chemical, Receptor-CD3 Complex, Antigen, T-Cell, Receptors, Antigen, T-Cell, alpha-beta, T-Lymphocytes, Receptors, Antigen, T-Cell, Signal Transduction
Major Histocompatibility Complex, CD3 Complex, Models, Chemical, Receptor-CD3 Complex, Antigen, T-Cell, Receptors, Antigen, T-Cell, alpha-beta, T-Lymphocytes, Receptors, Antigen, T-Cell, Signal Transduction
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