[Radiation-protective effect of agonists of alpha-2 adrenergic receptors. Methyldopa].

V I, Kulinskiĭ; V Iu, Kovtun; V G, Iashunskiĭ; A L, Klimova

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Article . 1997

Data sources: Europe PubMed Central

[Radiation-protective effect of agonists of alpha-2 adrenergic receptors. Methyldopa].

descriptionPublicationkeyboard_double_arrow_right Article 29 Dec 1997 Russian Journal:Radiatsionnaia biologiia, radioecologiia, volume 37 (issn: 0869-8031,

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Authors: V I, Kulinskiĭ; V Iu, Kovtun; V G, Iashunskiĭ; A L, Klimova;

pmid: 9417302

[Radiation-protective effect of agonists of alpha-2 adrenergic receptors. Methyldopa].

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Abstract

MethylDOPA has the considerable (60-80%) and lasting RPE at both intraperitoneal (0.5-3.8 mmol/kg) and per os (3.8-7.1 mmol/kg) introduction in radiation dose 8 Gr (LD97/30). Optimal time for introduction is 0.5-3.0 hours intraperitoneally and 3-6 hours per os. Evidently, methylDOPA RPE is realized via alpha 2-adrenoceptors.

Keywords

Mice, Inbred C57BL, Mice, Time Factors, Mice, Inbred CBA, Administration, Oral, Animals, Female, Radiation-Protective Agents, Methyldopa, Radiation Dosage, Adrenergic alpha-Agonists, Injections, Intraperitoneal

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