Recently several studies have suggested a decline in the quality of semen. About half of the infertile causes are in men, the rate is increasing in the infertile couples. There are some therapy for the male sterility; medication, surgery or assisted reproductive technology (ART). Medicinal effects are not expected, and surgical cases are localized for indication. Moreover, since most of male sterility are idiopathic insufficiency of spermatogenesis, a recent tendency in the male sterile therapy is ART such as IVF-ET, ICSI, TESE, etc.