[Antibodies against alpha-2 and gamma-interferons affect the course of juvenile respiratory papillomatosis in children treated with alpha-2 interferon preparations].
Copyright policy )[Antibodies against alpha-2 and gamma-interferons affect the course of juvenile respiratory papillomatosis in children treated with alpha-2 interferon preparations].
1-year or longer treatment of juvenile respiratory papillomatosis (JRP) with alpha-2 interferons (A21) leads to emergence of antibodies to A21 in 54.3% of the patients. The greatest percentage of the antibody positives (94.4%) was found among JRP patients treated with intramuscular recombinant human A21 (reaferon). The proportion of the antibodies carriers fell to 15.4% if reaferon was used as a component of the new preparation viferon. JRP patients have also autoantibodies to A21 and gamma-interferon (8.74 and 33.3%, respectively). Patients with autoantibodies to gamma-interferon responded well to treatment with A21. Antibodies to A21 seem to have no negative effect on interferon therapy of JRP. Reaferon and viferon can be effectively used in JRP treatment.
Adolescent, Papilloma, Infant, Antibodies, Recombinant Proteins, Interferon-gamma, Child, Preschool, Interferon Type I, Humans, Child, Autoantibodies
Adolescent, Papilloma, Infant, Antibodies, Recombinant Proteins, Interferon-gamma, Child, Preschool, Interferon Type I, Humans, Child, Autoantibodies
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).0 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!