Does plasma ANP participate in natriuresis induced by alpha-MSH?

D L, Picanço-Diniz; G, Ribeiro-Oliveira; A L, Favaretto; J, Gutkowska; S M, McCann; J, Antunes-Rodrigues

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Brazilian Journal of Medical and Biological Research

Article . 1997

Data sources: Europe PubMed Central

Does plasma ANP participate in natriuresis induced by alpha-MSH?

descriptionPublicationkeyboard_double_arrow_right Article 19 Nov 1997 English Journal:Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica, volume 30 (issn: 0100-879X,

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Authors: D L, Picanço-Diniz; G, Ribeiro-Oliveira; A L, Favaretto; J, Gutkowska; S M, McCann; J, Antunes-Rodrigues;

pmid: 9251765

Does plasma ANP participate in natriuresis induced by alpha-MSH?

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Abstract

alpha-Melanocyte-stimulating hormone (alpha-MSH; 0.6 and 3 nmol) micro-injected into the anteroventral region of the third ventricle (AV3V) induced a significant increase in diuresis without modifying natriuresis or kaliuresis. Intraperitoneal (ip) injection of alpha-MSH (3 and 9.6 nmol) induced a significant increase in urinary sodium, potassium and water excretion. Intraperitoneal (3 and 4.8 nmol) or iv (3 and 9.6 nmol) administration of alpha-MSH did not induce any significant changes in plasma atrial natriuretic peptide (ANP), suggesting that the natriuresis, kaliuresis and diuresis induced by the systemic action of alpha-MSH can be dissociated from the increase in plasma ANP. These preliminary results suggest that alpha-MSH may be involved in a gamma-MSH-independent mechanism of regulation of hydromineral metabolism.

Related Organizations

Universidade Federal do Pará
Brazil

Keywords

Male, alpha-MSH, Animals, Natriuresis, Rats, Wistar, Atrial Natriuretic Factor, Cerebral Ventricles, Diuresis, Rats

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