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Экспериментальная и клиническая фармакология

Article . 1997

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[The cardiotoxic properties of anti-arrhythmia agents].

descriptionPublicationkeyboard_double_arrow_right Article 30 Jun 1997 Russian Journal:Eksperimental'naia i klinicheskaia farmakologiia, volume 60 (issn: 0869-2092,

Authors: A A, Spasov; N A, Gurova;

pmid: 9206561

[The cardiotoxic properties of anti-arrhythmia agents].

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Abstract

Experiments were conducted on cats to study the cardiotoxic and arrhythmogenic properties of some antiarrhythmic agents in continuous intravenous infusion in doses multiple of the dose which causes an antiarrhythmic effect on an acontic model of arrhythmia in rats in 50% of cases. Novocainamide, cordarone, bonnecor, and quinidine possessed the most marked cardiotoxicity. A less marked cardiodepressive activity was encountered in the case of ethmosine and ethacysin. The appearance of the cardiodepressive properties of the agents depended on the rate of their injection. The results of the study testify to the possibility of prognosticating the arrhythmogenic and cardiodepressive effects in experimental investigation of new antiarrhythmic agents.

Keywords

Male, Dose-Response Relationship, Drug, Hemodynamics, Arrhythmias, Cardiac, Heart, Lethal Dose 50, Depression, Chemical, Cats, Animals, Female, Infusions, Intravenous, Anti-Arrhythmia Agents

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