Salazosulfapyridine suppresses chondrocyte mediated degradation induced by interleukin 1beta.
Copyright policy )Salazosulfapyridine suppresses chondrocyte mediated degradation induced by interleukin 1beta.
To investigate the effects of salazosulfapyridine (SASP) and methotrexate (MTX) on interleukin (IL)-1beta treated rabbit chondrocytes.Normal rabbit chondrocytes were cultured to confluency. IL-1beta was added to serum-free culture medium in the presence or absence of SASP or MTX. After 2 days' incubation, the effects were evaluated from the responses of metalloproteinases, glycosaminoglycan (GAG), and prostaglandin E2 (PGE2).SASP and MTX suppressed GAG and collagenase release into the culture medium from IL-1beta stimulated rabbit chondrocytes in a dose dependent manner. Only SASP suppressed stromelysin and PGE2 release.SASP may have a protective effect on cartilage degradation of patients with rheumatoid arthritis.
Cartilage, Articular, Knee Joint, Cell Survival, Metalloendopeptidases, Dinoprostone, Sulfasalazine, Methotrexate, Animals, Rabbits, Glycosaminoglycans, Interleukin-1
Cartilage, Articular, Knee Joint, Cell Survival, Metalloendopeptidases, Dinoprostone, Sulfasalazine, Methotrexate, Animals, Rabbits, Glycosaminoglycans, Interleukin-1
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